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Bad housekeeping

Bad housekeeping

作者:罗脱杂  时间:2019-03-07 10:16:00  人气:

A FAULTY “housekeeping” gene damages nerves by allowing rubbish to pile up inside cells, say researchers in Japan. The brain cells of people with neurodegenerative diseases such as Parkinson’s or Alzheimer’s often accumulate bits of non-degraded proteins, and physicians have long suspected that this cellular trash might damage neurons. Now Keiji Wada of the National Institute of Neuroscience in Tokyo and his colleagues have found that mice with neural degeneration have a mutant form of a gene called gad (Nature Genetics, vol 23, p 47). Gad normally codes for an enzyme needed to produce a protein that tags cellular garbage for removal. “We are going to investigate how this mutant enzyme damages cells,